Event description

Quantitative and cost-effective Positron Emission Tomography: towards multi-parametric molecular imaging and utilization of sparsely- distributed detectors configurations

Dr. Nicolas (Nikolaos) A. Karakatsanis, graduate of our school and Assistant Professor in Biomedical Engineering at the Department of Radiology at Weill Cornell Medicine, Cornell University in New York, will give a lecture entitled “Quantitative and cost-effective Positron Emission Tomography: towards multi-parametric molecular imaging and utilization of sparsely-distributed detectors configurations” on Tuesday, October 22, 2019, at 14:00 at the Multimedia Amphitheater of the National Technical University of Athens Central Library. The event is organized by IEEE Greece Section in cooperation with IEEE NTUA EMB Chapter and IEEE NTUA Student Branch and the Biomedical Simulations and Imaging (BioSim) Laboratory of the School of Electrical and Computer Engineering.

Abstract: Positron Emission Tomography (PET) has been established as a highly sensitive molecular imaging modality capable of providing non-invasive, diagnostic and treatment response assessments by quantifying the activity of specific molecular processes underlying a spectrum of oncologic, cardiovascular and neurologic diseases. In this seminar talk, we will initially present the basic principles of data acquisition, image reconstruction and quantification in clinical standard-of-care PET exam protocols. Then, we will discuss clinically adoptable dynamic PET acquisition protocols coupled with robust radiotracer graphical analysis and kinetic modeling methods to extract
additional PET quantitative features related to the spatio-temporal (4D) activity of the targeted molecular processes. The new multi-parametric molecular imaging method is aiming to enhance PET-driven diagnostic and treatment response assessments. Finally, we will complete our clinical PET review with the presentation of recent cost-effective PET instrumentation solutions to extend the limited (~26cm) axial field-of-view (AFOV) of current generation human PET systems by a factor of more than two (~55cm), without significantly increasing the PET system’s manufacturing cost. This novel technology exploits 4D PET Time-of-Flight acquisitions with a sparsely-distributed detectors configuration in continuous bed motion to enable truly simultaneous imaging of multiple organs at large distance to each other, such as that of the heart and the brain, at a clinically affordable cost.